Sinemet is a combination product (levodopa and carbidopa) which is used to treat Parkinson's disease.


Sinemet is a combination product containing two medications: levodopa and carbidopa. It is used to treat Parkinson's disease. Levodopa helps to control the symptoms of Parkinson's disease by correcting the chemical imbalance in the brain that produces symptoms. Although Sinemet helps relieve symptoms of Parkinson's disease, it does not slow down the progression of the disease.



Hypersensitivity, angle-closure glaucoma, severe psychosis or psychoneurosis, melanoma and suspicion of it, and skin diseases of unknown etiology, pregnancy, lactation, age up to 12 years. With caution. Myocardial infarction with rhythm disturbances (history), bronchial asthma, lung disease, epileptic seizures (history), erosive and ulcerative lesions of the gastrointestinal tract, diabetes mellitus and other decompensated endocrine diseases, severe liver and / or kidney failure, CHF.

How to apply: dosage and course of treatment

Inside, 1/4 tablet (250 mg / 25 mg) 2-3 times a day, then increase the dose by 1/4 tablet every 2-3 days until the optimal effect is achieved. Usually, the optimal effect is noted at a dose of 1-2 tablets (250 mg / 25 mg) per day. The maximum daily dose is 1.5 g of levodopa and 150 mg of carbidopa (6 tablets of 250 mg / 25 mg).


special instructions

At the beginning of treatment: nausea, vomiting, loss of appetite, epigastric pain, dysphagia, ulcerogenic effect (in predisposed patients); in some cases - rhythm disturbances, orthostatic hypotension. In the course of further treatment - spontaneous movements (hyperkinesis), dyskinesia. Hemolytic anemia, leukopenia, thrombocytopenia. Mental disorders, insomnia, irritability, depression. Tachycardia, constipation, weight gain (with prolonged use). special instructions It is unacceptable to suddenly stop taking levodopa (with a sharp cancellation, a symptom complex may develop, resembling a malignant neuroleptic syndrome, including muscle rigidity, fever, mental abnormalities and an increase in serum CPK activity).
It is necessary to monitor patients who need to suddenly reduce the dose of the drug or stop taking it, especially if the patient is receiving antipsychotic drugs.
Not prescribed to eliminate extrapyramidal reactions caused by drugs.
In the process of treatment, it is necessary to control the mental status of the patient, the picture of peripheral blood.
Foods high in protein may interfere with absorption.
Patients with glaucoma while taking the drug should regularly monitor intraocular pressure.
It is recommended to take with food or with a small amount of liquid, the capsules are swallowed whole.
During long-term treatment, it is advisable to periodically monitor the functions of the liver, hematopoiesis, kidneys and CCC.
Before the planned general anesthesia, the drug can be taken as long as the patient is allowed oral administration.
After surgery, the usual dose may be re-administered as soon as the patient is able to take the drug orally.
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.